Abstract: Species distribution models (SDMs) are widely used by researchers and conservationists. Results of prediction from different models vary significantly, which makes users feel difficult in selecting models. In this study, we evaluated the performance of two commonly used SDMs, the Biomod2 and Maximum Entropy (MaxEnt), with real presence/absence data of giant panda, and used three indicators, i.e., area under the ROC curve (AUC), true skill statistics (TSS), and Cohen’s Kappa, to evaluate the accuracy of the two model predictions. The results showed that both models could produce accurate predictions with adequate occurrence inputs and simulation repeats. Comparedto MaxEnt, Biomod2 made more accurate prediction, especially when occurrence inputs were few. However, Biomod2 was more difficult to be applied, required longer running time, and had less data processing capability. To choose the right models, users should refer to the error requirements of their objectives. MaxEnt should be considered if the error requirement was clear and both models could achieve, otherwise, we recommend the use of Biomod2 as much as possible.