欢迎访问《应用生态学报》官方网站,今天是 分享到:

应用生态学报 ›› 2017, Vol. 28 ›› Issue (5): 1735-1742.doi: 10.13287/j.1001-9332.201705.018

• 综合评述 • 上一篇    

细菌群体感应“合作-欺骗”研究进展

赖柏民1, 汪美贞1,2*, 沈东升1,2   

  1. 1浙江工商大学环境科学与工程学院, 杭州 310012;
    2浙江省固体废物处理与资源化重点实验室, 杭州 310012
  • 收稿日期:2016-09-24 修回日期:2017-02-20 发布日期:2017-05-18
  • 通讯作者: *E-mail: wmzyy@163.com
  • 作者简介:赖柏民, 男, 1991年生, 硕士研究生. 主要从事微生物群体感应研究. E-mail: laibaimin2010@163.com
  • 基金资助:
    本文由国家自然科学基金项目(31570490)和浙江省自然科学基金项目(LY15C010001, LQ14B070001)资助

Bacterial quorum sensing: Cooperation and cheating

LAI Bai-min1, WANG Mei-zhen1,2*, SHEN Dong-sheng1,2   

  1. 1College of Environmental Science and Engineering, Zhejiang Gongshang University, Hangzhou 310012, China;
    2Zhejiang Province Key Laboratory of Solid Waste Treatment and Recycling, Hangzhou 310012, China
  • Received:2016-09-24 Revised:2017-02-20 Published:2017-05-18
  • Contact: *E-mail: wmzyy@163.com
  • Supported by:
    This work was supported by the National Science Foundation of China (31570490), and the Natural Science Foundation of Zhejiang Province (LY15C010001, LQ14B070001)

摘要: 细菌利用信号分子进行细胞间的交流即为群体感应.群体感应调控着生物膜形成、公共物质合成、基因水平转移等一系列社会性行为.在群体感应过程中,公共物质分泌后可以被群体中任何个体所使用即合作;亦可以被一些不分泌公共物质的个体所使用形成欺骗.群体感应合作-欺骗既可能在种群中稳定维持,也可能由于欺骗子的快速增长造成种群崩溃.欺骗子致种群崩溃为病原菌控制新策略研发带来了希望,是目前群体感应研究方面的前沿和热点.本文在介绍细菌群体感应合作及欺骗的基础上,分析了群体感应合作-欺骗生态关系形成和发展的影响因素,重点从亲缘选择、谨慎代谢、代谢限制(基因多效型)、群体感应监管等方面探讨了细菌群体感应合作-欺骗的稳定维持机制,并对细菌群体感应合作-欺骗的相关研究进行了问题总结和展望,以期为深入理解群体感应、微生物种群生态提供参考.

Abstract: Quorum sensing (QS), a cell-to-cell communication, regulates a variety of social beha-viors, such as biofilm formation, public goods produce and gene horizontal transfer of bacteria. In the process of quorum sensing, public goods could be utilized by any members in the population, which was termed as cooperation. Notably, public goods also could be shared by the individuals who could not produce them, which was termed as cheating. Once cheaters come up, they possibly maintain equilibrium with cooperators, meanwhile they also possibly induce the collapse of population due to their rapid growth and shortage of public goods. Therefore, invasion of cheaters arouses wide attentions in medicine, agriculture, food science and so on regarded as a new strategy to control pathogens. In this study, based on the introduction about the theory of bacterial quorum sensing cooperation and cheating, we analyzed the factors influencing the formation and development of the relationship between cooperator and cheater. Moreover, we discussed the mechanism of stabilization in the relationship between cooperator and cheater, including kin selection, metabolic prudence, metabolic constraint (gene pleiotropy) and policing quorum sensing. Finally, some problems in current researches of quorum sensing cooperation and cheating were presented as well as the future research directions. We hoped this paper could deepen the understanding of bacterial quorum sen-sing and ecology of bacterial population.