兽药的生态毒理及其对环境影响的研究进展

摘要/Abstract

摘要： 药物在环境中的转归和对生态环境的潜在影响已成为国际上研究的热点.兽药以原形或代谢产物形式经畜禽粪尿排出体外,沿不同的路径进入环境.在各种环境因素的作用下,通过不同的方式发生转归.环境中的兽药不仅可以影响不同的生物种群,而且通过不同生物间的关系,影响生态系统.就兽药在环境中的染毒线路、转归、兽药对环境生物(动物、植物、微生物)和土壤过程的影响等方面进行了论述,并简述了药物环境风险评估的重要性.

中图分类号:

X171.5

刁晓平, 孙振钧, 沈建忠. 兽药的生态毒理及其对环境影响的研究进展[J]. 应用生态学报, 2004, (2): 321-325.

DIAO Xiaoping, SUN Zhenjun, SHEN Jianzhong . Research advance in ecotoxicology and environmental impact of veterinary medicines[J]. Chinese Journal of Applied Ecology, 2004, (2): 321-325.

参考文献

[1] Baguer Al, Jensen J, Krogh PH. 2000. Effects of the antibiotics oxytetracycline and tyrosine on soil fauna. Chemosphere, 40: 751 ～757
[2] Batchelder AR. 1981. Chlortetracycline and oxytetracycline effects on plant growth and development in liquid culture. J Environ Qual, 10: 515～ 518
[3] Bewick MW. 1978. Effect of tyrosine and tyrosine-fermentation waste on microbial activity of soil. Soil Biol Biochem, 10:403～407
[4] Carson RL 1962. Silent Spring. Boston: Houghton Mifflin.
[5] Cater A, Keeney EA, Gutheir TF, et al. 1983. Heavy metals in earthworms in non-contaminated and contaminated agricultural soil from near Vancouver, Canada. In: Satchell JE ed. Earthworm Ecology. London: Chapman and Hall. 267 ～274
[6] Chang C, Sommerfeldt TG, Entz T. 1993. Barley performance under heavy application of cattle feedlot manure. Agron J, 85:1013～1018
[7] Chen Z-L(陈杖榴),Yang G-X(杨桂香),Sun Y-X(孙永学),et al. 2001. Advance of toxicities and ecotoxicology of veterinary drug residues J South China Agric Univ(华南农业大学学报),22(1):88～ 91 (in Chinese)
[8] Dijck PV, van de Voorde H. 1976. Sensitivity of environmental microorganism to antimicrobial agents. Appl Environ Microbiol, 31:332～ 336
[9] Dong S-Y (董书芸). 1996. Advances of environmental pollutants on immunefunction of fish.J Environ Health(环境与健康杂志),13 (6): 282～ 284 (in Chinese)
[10] Edwards CA, Thompson AR. 1973. Pesticides and the soil fauna.Residue Rev, 45: 1 ～ 79
[11] Edwards CA. 2000. Soil invertebrate controls and microbial interactions in nutrient and organic matter dynamics in natural and agroecosystems. In: Coleman DC, Hendrix PF eds. Vertebrate as Webmasters in Ecosystems. Oxford: CABI Publishing. 141 ～ 159
[12] Elmund GK, Morrison SM, Grant DW, et al. 1971. Role of excreted chlortetracycline in modifying the decomposition process in feedlot waste. Bull Environ Contamin Toxicol, 6:129～ 132
[13] Halley BA, Jacob TA, Lu AY. 1989a. The environmental impact of the use of ivermectine, environmental effects and fate. Chemosphere, 18:1543～ 1563
[14] Halling-Sorensen B, Nielsen N, Lansky PF, et al. 1998. Occurrence, fate and effects of pharmaceuticals in the environment-A review. Chemosphere, 36; 357～ 394
[15] Heberer T. 2002. Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: A review of recent research data. Toxicol Letter, 131: 5 ～ 17
[16] Hirsch R, Ternes T, Haberer K, et al. 1999. Occurrence of antibiotics in the aquatics environment. Sci Total Environ, 36; 3573 ～3593
[17] Holten L, Liitzhoft HC, Hailing-Sorensen B, et al. 1999. Algal toxicity of antibacterial agents applied in Danish fish farming. Arch Environ Contam Toxicol, 36: 1 ～ 6
[18] Ingerslev F, Holten Lutzhoft HC, Halling-Sorensen B. 1999. Humant anvendte lagemidlers vej til miljoet er gannem rensningsanlagget. Dansk Kemi, 80(6～7):222～225(in Danish)
[19] Jacobsen P, Berglind L. 1988. Persisitence of oxytetracycline in sediments from fish farm. Aquaculture, 70: 365～ 370
[20] Jemba PK. 2002. The potential impact of veterinary and human therapeutic agents in manure and biosolid on plant grow on arable land: A review. Agric Ecosyst Environ, 93: 267～ 278
[21] Jorgensen SE, Halling-Sorensen B. 2000. Drugs in the environment.Chemosphere, 40: 691 ～ 699
[22] Kuhne M, Ihnen D, Moller G, et al. 2000. Stability of tetracycline in water and liquid manure. J Vet Med Ser A - Physiol Pathol Clin Med, 47: 379～ 384
[23] Kiimmerer K, Hartmanm T, Meyer M. 1997. Biodegradability of the anti-tumor agent ifosfamide and its occurrence in hospital effluents and sewage. Water Res, 31: 2705～ 2710
[24] Lerch RN, Barbarick KA, Westfall DG, et al. 1990. Sustainable rates of sewage sludge for dry land winter wheat production. Part Ⅱ. Production and income. J Prod Agric, 3: 66 ～ 71
[25] Loke MT, Tjornelund J, Hailing-sorensen B. 2002. Determination of the distribution coefficient (log Kd) of oxytetracycline, tylosine A, olaquindox and metronidazole in manure. Chemosphere, 48:351～361
[26] Migliore L, Brambilla G, Cozzolino S, et al. 1995. Effects on plants of sulfphadimethoxine used in intensive farming (Panicum milieceum, Pisum sativum and Zea mays ). Agric Ecosyst Environ,52:103～ 110
[27] Migliore L, Brambilla G, Casoria P, et al. 1996. Effects of sulfphadimethoxine on barley in Laboratory terrestrial models. Agric Ecosyst Environ, 60:121 ～ 128
[28] Miyazaki A, Amano T, Seito H, Nakano Y. 2002. Acute toxicity of chlorophenols to earthworms using a simple paper contact method and comparison with toxicities to fresh water organisms, Chemosphere, 47: 65 ～ 69
[29] Nimenya H, Delaunosis, A, La duong D, et al. 1999. Short-term toxicity of various pharmacological agents on the in vitro nitrification process in a simple closed aquatic system. Alta-Alter Lab Anim, 27:121～ 135
[30] Qiu J-P(邱江平). 1999. The application of earthworm in environmental protection.Acta Shanghai Agric Coll(上海农学院学报),17(3) :227～232 (in Chinese)
[31] Rabolle M, Spliid NH. 2000. Sorption and mobility of metronidazole,olaquindox, oxytetracycline and tylosin in soil. Chernosphere,40:715～712
[32] Radix P, Leonard M, Papantoniou C, et al. 2000. Comparison of four chronic toxicity tests using algae, bacteria, and invertebrates asseseed with sixteen chemicals. Ecotoxicol Environ Safety, 47:186～ 194
[33] Richardson ML, Bowron JM. 1985. The fate of pharmaceutical chemicals in the aquatic environment--A review. J Phar Pharmaco,37:1～12
[34] Samuelsen OB, Torsvik A. 1992. Long-range changes in oxytetracycline concentration and bacterial resistance toward oxytetracycline in a fish sediment after medication. Soil Total Environ, 114:25～36
[35] Smith SR. 1996. Agricultural Recycling of Sewage Sludge and the Environment. Wallingford, Oxon, UK: CAB International.
[36] Warman PR. 1980. The effect of amprolium and auromycin antibiotics on the nitrification of poultry manure-amended soil. J Soil Sci Am, 44:1333～ 1334
[37] Wollenberger L, Hailing-Sorensen B, Kusk KO. 2000. Acute and chronic toxicity of veterinary antibiotics to Daphnia magna. Chemosphere, 40: 723 ～ 730
[38] Young HK. 1993. Antimicrobial resistance spread in aquatic environments. J Antimicrob Chemother, 31: 627～ 635
[39] Yang J-Y(杨居荣),GE J-E(葛家二),et al.1982.The effect of arsenic and heavy metal on soil microbials.J Environ Sci(环境科学学报),2(2):190～197(in Chinese)
[40] Yang J-Y(杨居荣),RanY(任燕),LiuH(刘虹).1996.The effect of arsenic on soil microbial and biochemical activity.Soils(土壤),28(2):101～104(in Chinese)
[41] Zhang Y-H(张跃华),Luo Z-W(罗志文),Zhao Y-X(赵永勋).2002. The effect of averment on the activity of soil microbiology. J Jiamusi Univ(Natural ScienceEdition)(佳木斯大学学报)(自然科学版),20(1):49～51(in Chinese)