Based on the hydrological data from the Beikouqian and Nandianyu stations in the upstream of Hun River and Taizi River as well as the meteorological data from the Qingyuan, Xinbin, and Benxi County stations, Northeast China in 1998-2007, a distributed hydrological model (DHSVM) was applied to simulate the hydrological process in Hun-Tai basin. The scientific applicability of the model was validated, and the reference values of the most sensitive model parameters were provided. The simulated monthly runoff NashSuttclife coefficient (E _value) for the source region of Hun River in calibration period (1998-2002) and validation period (2003-2007) was 0.9675 and 0.8957, respectively, which could better reappear the monthly runoff process in this source region. The simulated monthly and annual runoff E_values for the upstream of Taizi River were greater than 0.6, indicating that this model had good applicability in Hun-Tai basin, and the calibrated parameter scheme had a good reliability. This paper established a solid framework for the hydrological study over ungauged basin, and constructed a reasonable parameter scheme.