Abstract: To provide theoretical basis for the water-saving, high-yield and good quality cultivation techniques of drip-irrigated winter wheat, the wheat cultivar ‘Xindong 22’ was adopted as the test material, and five irrigation amounts including 3150 (W₁), 3900 (W₂), 4650 (W₃), 5400 (W₄) and 0 (CK) m³·hm^-2 were adopted to investigate effects of drip irrigation amount on grain filling dynamics and quality traits in 2012-2013 and 2013-2014 wheat growing seasons in Xinjiang. Results indicated that the grain-filling dynamics of drip-irrigated winter wheat in different treatments presented the “S” shape curve, and accorded with the Logistic model with high fitting degree. The fast increase period of wheat grain-filling was measured at 12-20 days after anthesis. The maximum filling rate (V_m) increased at first and decreased later with the increase of drip irrigation amount, and was obtained in the treatment W₃ in the two seasons, which was 2.16 g·d ^-1and 2.59 g·d ^-1, respectively. With the increase in drip irrigation amount, the bulk mass, protein content, flour extraction rate, wet gluten content, dough stability time, degree of softening, dough extension resis-tance and draw ratio of the drip-irrigated wheat firstly increased and decreased later, and the maxima of these indexes were measured in W₃. However, the water absorption rate and extensibility of dough initially decreased and then increased, and the minimum was obtained in the treatment of W₃. The sedimentation value increased gradually and the dough development time decreased progressively. Treatment W₃ had the highest grain yield of 8913 kg·hm^-2 in 2013 and 8602 kg·hm^-2 in 2014, which was 25.0%, 14.8%, 4.4%, 35.6% and 12.4%, 2.8%, 1.1%, 33.0% higher than the treatments of W₁, W₂, W₄ and CK in 2013 and 2014, respectively. In conclusion, drip irrigation of 4650 m³·hm^-2 during the whole growing season of winter wheat could realize the target of high-yield and good quality in local natural condition.