Abstract: Land reclamation from lake marsher could increase grain yield and teneficial for eliminatingoncomelania,but also created ecologically negative effects in aquatic product industry,cli-mate and water transport.Therefore rational exploitation of lake rescurces was suggested inHubei province which has vast lake resources.

Key words: Proliferation, 2-keto-L-gulonic acid, Mixed culture, Gluconobacter oxydans, Bacillus megaterium