Shen’ao Bay is one of the typical marine culture bases in the eastern Guangdong Province. Long-term mariculture activities lead to some environmental problems, such as eutrophication. In this paper, the pressurestateresponse model (PSR) was used to evaluate the health status of mariculture ecosystem in Shen’ao Bay with the fuzzy comprehensive evaluation method. The results showed the membership of Shen’ao Bay was 0.4983, suggesting that the ecosystem was in a very healthy state. The maximum memberships of the seven ecological elements were 0.5717, 0.3714, 0.5215, 0.5942, 0.6014, 0.7792, and 0.6562, respectively. Except that the membership of direct pressure element was in unhealthy and subhealth states, the other remained elements were above healthy levels. The main factors affecting the overall healthy status of the ecosystem included the excessive varieties of cultivation and the excessively large cultivation area. In addition, the low primary productivity and the low annual growth rate of aquaculture production contributed, to some extent, to the overall unhealthy status.