Abstract: The effect of enhanced-efficiency nitrogen (N) fertilizers on emissions of nitrous oxide (N₂O) from the grey desert agricultural soils of Xinjiang is uncertain. In this study, the enhanced-efficiency fertilizers, polymer-coated urea (ESN), and stabilized urea with urease and nitrification inhibitors (U+I) were compared to conventional urea (U) for N₂O emissions from cotton under plastic mulch drip irrigation near Urumqi, Xinjiang. ESN was added once at planting but the other treatments were added multiple times with drip irrigation during the growing season. Gas samples were collected and analyzed twice per week during the growing season, using the static chamber-chromatography methodology. The results showed that generally, ESN significantly increased soil cumulative N₂O emissions during the growing season by 47%-73% compared to other treatments. In the first four months after fertilization, soil ammonium (NH₄⁺-N) and nitrate (NO₃^--N) concentrations under ESN treatment were generally higher than under other treatments. Thereafter, NH₄⁺-N and NO₃^--N concentrations under all treatments gradually decreased to similar levels. ESN all added at planting was likely responsible for high NH₄⁺-N and NO₃^--N concentrations and highest N₂O emissions. The U+I treatment reduced soil N₂O emission by 9.9% in comparison with U, whereas the difference was not statistically significant. In addition, soil NO₃^--N contents of the U+I treatments were generally lower than those of the ESN and the U treatments. The cumulative N₂O emissionsover the growing season ranged from 300 to 500 g N₂O-N·hm^-2, generally lower than emissions reported for other agricultural ecosystems. Drip irrigation successfully kept moisture conditions below levels for appreciable N₂O emissions. Multiple applications of N via drip irrigation seemed to be effective to lower emissions than all N applied at planting. Therefore, for cotton field under plastic mulch drip irrigation in arid land of Northwest China, the benefit of enhanced efficiency N ferti-lizers on N₂O mitigation is limited.