Research advances in DNA adducts:Their formation,diagnosis and pollution-exposure indication

Abstract

Abstract: With the cognitive penetration of ecotoxicological effects into a molecular level,more attention has been paid to the research on DNA adducts.This paper analyzed toxic mechanisms and formative processes of DNA adducts,and introduced in brief their diagnostic methods,including chromatogram-mass spectrum method, ³²P post-labeling method,immunology method and fluorescence method.The pollution-exposure indication of DNA adducts was expounded as an effective molecular biomarker,and thus,DNA adducts could be used by ecotoxicologists as a good caution signal in forecasting hazardous effects of pollutants.

Key words: DNA adduct, Ecotoxicological effect, Molecular biomarker

CLC Number:

X171.5

WANG Mei'e, ZHOU Qixing. Research advances in DNA adducts:Their formation,diagnosis and pollution-exposure indication[J]. Chinese Journal of Applied Ecology, 2004, (10): 1983-1987.

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