Abstract: Reasonable irrigation is still lacking for potato production in the sandy areas of Yulin, northern Shaanxi Province. To solve this problem, field drip fertigation was conducted to examine the growth, yield and quality of potato during the whole growing season. We further analyzed the responses of these indices to different irrigation frequencies and amounts. There were three irrigation frequencies (d), i.e. 4 (D₁), 8 (D₂) and 10 (D₃), and three irrigation amounts, i.e. 60%ET_c (W₁), 80%ET_c(W₂) and 100%ET_c(W₃), where ET_c was the crop water requirement, resulting in a total of nine treatments. Under the same irrigation frequency, plant height, leaf area index, dry matter, tuber yield and economic benefits of W₃ were higher than those of W₁ and W₂. W₁ had the highest irrigation water use efficiency (IWUE), while water use efficiency was not significantly affected by irrigation amount. The average tuber yield of W₃ was 43442 kg·hm^-2, which was 23.3% and 11.6% higher than that of W₁ and W₂, respectively. The net income of W₃ was 23492 yuan·hm^-2, which was 40.4% and 18.7% higher than that of W₁ and W₂, respectively. Tubers from W₃ had the highest starch and vitamin C contents but the lowest reducing sugar content, which were 14.4%, 18.54 mg·(100 g)^-1 FW and 0.7%, respectively. At the same irrigation amount, tuber yield, IWUE, starch and vitamin C contents of D₁ were the highest, but the reducing sugar content was the lowest at the low and medium irrigation amounts. At the high irrigation amount, D₂ had the highest tuber yield, IWUE, net income, starch and vitamin C contents but the lowest reducing sugar content, which were 46572 kg·hm^-2, 23.04 kg·m^-3, 26,622 yuan·hm^-2,14.6%, 19.53 mg·(100 g)^-1 FW and 0.7%, respectively. Based on the interacting effects of drip irrigation frequency and amount, both yield and quality of D₂W₃ reached the maximum. Results from the principal component analysis showed that D₂W₃ had the highest score. D₂W₃(8 d, 100%ET_c) had the greatest yield and quality and relatively higher water use efficiency, which was thus considered as the optimal combination of drip irrigation frequency and amount. The results could provide a scientific basis for the drip irrigation scheduling design for high-yield, high-efficiency and high-quality potato production in the sandy areas of Yulin, northern Shaanxi.