Toxicological study of three veterinary drugs on Eisenia foetida

Abstract

Abstract: By the methods of acute toxicity test and single cell gel electrophoresis (comet assay),this paper evaluated the toxicological effects of three veterinary drugs olaquindox,arsanilic acid and oxytetracycline on earthworm (Eisenia foetida) coelomocytes in vivo.The results of acute toxicity test showed that only the highest dose of olaquidox caused the death of some earthworms,and none of the test drugs had any effects on earthworm at their environmentally relevant concentrations.The comet assay indicated that arsanilic acid had no genotoxicity to earthworm,while olaquindox and oxytetracycline induced significant DNA damage in earthworm coelomocytes (P<0.01).

Key words: Veterinary additives, Olaquindox, Arsanilic acid, Oxytetracycline, Eisenia foetida, Acute toxicity test, Single cell gel electrophoresis test(SCGE)

CLC Number:

X172

QU Mengmeng, XU Yun, CHEN Haigang, LI Zhaoli, SUN Liwei, XU Dijin, KONG Zhiming, SUGIURA Norio . Toxicological study of three veterinary drugs on Eisenia foetida[J]. Chinese Journal of Applied Ecology, 2005, 16(6): 1108-1111.

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