Abstract: A pot experiment with heavy metals- contaminated black soil from Heilongjiang Province, alluvial soil from Henan Province, and paddy soil from Zhejiang Province was conducted to study the effects of intercropping Sedum plumbizincicola in wheat growth season under wheat (Triticum aestivum)-rice (Oryza sativa) rotation on the growth of the crops and their heavy metals uptake, aimed to explore the feasibility of simultaneous grain production and heavy metals- contaminated soil phytoremediation in main food crop production areas of this country. Comparing with monoculture T. aestivum, intercropping S. plumbizincicola increased the soil NaNO₃-extractable Zn and Cd significantly, with the increment of extractable Zn in test paddy soil, alluvial soil, and black soil being 55%, 32% and 110%, and that of extractable Cd in test paddy soil and black soil being 38% and 110%, respectively. The heavy metals concentration in T. aestivum shoots under intercropping S.plumbizincicola was 0.1-0.9 times higher than that under monoculture T. aestivum, but the intercropping had little effects on the rice growth and its heavy metals uptake. Though the Cd concentration in rice grain after S. plumbizincicola planting was still higher than 0.2 mg·kg^-1(the limit of Cd in food standard),it presented a decreasing trend, as compared with that after monoculture T. aestivum. Therefore, intercropping S.plumbizincicola in wheat growth season under wheat-rice rotation could benefit the phytoremediation of heavy metals- contaminated soil, and decrease the food-chain risk of rotated rice.