中国抗生素污染现状及对浮游生物的影响

doi:10.13287/j.1001-9332.202303.030

摘要/Abstract

摘要： 近年来,抗生素在水体中不断被检出,已经成为重要的环境污染问题,中国抗生素污染问题尤为严重。然而,当前人们对抗生素生态危害的认知主要集中在诱导病原微生物产生抗药性上,将抗生素污染视作危害人类健康的公共安全问题,却相对忽视了它对水生生物的潜在风险。浮游生物作为水生态系统的重要组成成分,对维持水生态系统稳定具有重要作用;同时,浮游生物对环境变化非常敏感。了解抗生素对浮游生物的影响是评估其生态风险的基础。为此,本文归纳了当前国内水环境中抗生素污染现状,分析了抗生素对浮游生物的影响。今后,除了利用代谢组学技术进一步揭示抗生素对浮游生物个体危害的机制外,还需加强野外抗生素与浮游生物群落的监测。

关键词: 抗生素污染, 浮游植物, 浮游动物, 代谢组学技术, 野外研究

Abstract: In recent years, antibiotics have been continuously detected in waterbodies and thus has become an environmental problem, especially in China. However, current knowledge regarding the ecological hazards of antibiotics is mainly focusing on the induction of resistance in pathogenic microorganisms, treating antibiotic contamination as a public safety problem that seriously endangers human health, but relatively ignores its potential risk to aquatic organisms. As an important component of aquatic ecosystems, plankton play an important role in maintaining the stability of aquatic ecosystems. Meanwhile, plankton are very sensitive to environmental changes. Therefore, understanding the impact of antibiotics on plankton is the basis for assessing their ecological risk. To this end, we summarized current status of antibiotic contamination in China’s aquatic environments, and analyzed the impacts of antibiotics on planktons. In addition to using metabolomics technology to reveal the negative impacts of antibiotics at the individual level, monitoring of antibiotics and plankton communities in the field needs to be strengthened in the future.

Key words: antibiotic contamination, phytoplankton, zooplankton, metabolomics technology, field study

李雅, 殷丽萍, 刘丹, 梁云权, 潘瑛. 中国抗生素污染现状及对浮游生物的影响[J]. 应用生态学报, 2023, 34(3): 853-864.

LI Ya, YIN Liping, LIU Dan, LIANG Yunquan, PAN Ying. Current situation of antibiotic contamination in China and the effect on plankton.[J]. Chinese Journal of Applied Ecology, 2023, 34(3): 853-864.

参考文献

[1] van Hoek AHAM, Mevius D, Guerra B, et al. Acquired antibiotic resistance genes: An overview. Frontiers in Microbiology, 2011, 2: 203
[2] Prajwal S, Vasudevan VN, Sathu T, et al. Antibiotic residues in food animals: Causes and health effects. The Pharma Innovation Journal, 2017, 6: 1-4
[3] Lorenzo P, Anzil A, Subirats J, et al. Antibiotic resis-tance in urban and hospital wastewaters and their impact on a receiving freshwater ecosystem. Chemosphere, 2018, 206: 70-82
[4] Luo Y, Xu L, Rysz M, et al. Occurrence and transport of tetracycline, sulfonamide, quinolone, and macrolide antibiotics in the Haihe River basin, China. Environmental Science & Technology, 2011, 45: 1827-1833
[5] Bagnis S, Fitzsimons MF, Snape J, et al. Processes of distribution of pharmaceuticals in surface freshwaters: Implications for risk assessment. Environmental Chemistry Letters, 2018, 16: 1193-1216
[6] Lyu J, Yang LS, Zhang L, et al. Antibiotics in soil and water in China: A systematic review and source analysis. Environmental Pollution, 2020, 266: 115147
[7] Storteboom H, Arabi M, Davis JG, et al. Tracking antibiotic resistance genes in the South Platte River basin using molecular signatures of urban, agricultural, and pristine sources. Environmental Science & Technology, 2010, 44: 7397-7404
[8] Zhao YG, Zhang SQ, Shu XD, et al. Effects of norfloxacin on decomposition and nutrient release in leaves of the submerged macrophyte Vallisneria natans (Lour.) Hara. Environmental Pollution, 2021, 274: 116557
[9] Pan Y, Dong JY, Wan LL, et al. Norfloxacin pollution alters species composition and stability of plankton communities. Journal of Hazardous Materials, 2020, 385: 121625
[10] Yao B, Yan SW, Lian LS, et al. Occurrence and indicators of pharmaceuticals in Chinese streams: A nationwide study. Environmental Pollution, 2018, 236: 889-898
[11] Leung HW, Minh TB, Murphy MB, et al. Distribution, fate and risk assessment of antibiotics in sewage treatment plants in Hong Kong, South China. Environment International, 2012, 42: 1-9
[12] Zhang HM, Liu PX, Feng YJ, et al. Fate of antibiotics during wastewater treatment and antibiotic distribution in the effluent-receiving waters of the Yellow Sea, northern China. Marine Pollution Bulletin, 2013, 73: 282-290
[13] Watkinson AJ, Murby EJ, Costanzo SD. Removal of antibiotics in conventional and advanced wastewater treatment: Implications for environmental discharge and wastewater recycling. Water Research, 2007, 41: 4164-4176
[14] Zuccato E, Castiglioni S, Bagnati R, et al. Source, occurrence and fate of antibiotics in the Italian aquatic environment. Journal of Hazardous Materials, 2010, 179: 1042-1048
[15] Gao P, Munir M, Xagoraraki I. Correlation of tetracycline and sulfonamide antibiotics with corresponding resistance genes and resistant bacteria in a conventional municipal wastewater treatment plant. Science of the Total Environment, 2012, 421: 173-183
[16] Tran NH, Chen HJ, Reinhard M, et al. Occurrence and removal of multiple classes of antibiotics and antimicrobial agents in biological wastewater treatment processes. Water Research, 2016, 104: 461-472
[17] Göbel A, McArdell CS, Joss A, et al. Fate of sulfonamides, macrolides, and trimethoprim in different wastewater treatment technologies. Science of the Total Environment, 2007, 372: 361-371
[18] Hirsch R, Ternes T, Haberer K, et al. Occurrence of antibiotics in the aquatic environment. Science of the Total Environment, 1999, 225: 109-118
[19] Ghosh GC, Okuda T, Yamashita N, et al. Occurrence and elimination of antibiotics at four sewage treatment plants in Japan and their effects on bacterial ammonia oxidation. Water Science & Technology, 2009, 59: 779-786
[20] 曹君, 张雪娇, 赵青, 等. 液相色谱紫外-荧光串联检测器法检测我国污水中常见11种抗生素. 生态学杂志, 2022, 41(1): 190-198
[21] Vieno N, Tuhkanen T, Kronberg L. Elimination of pharmaceuticals in sewage treatment plants in Finland. Water Research, 2007, 41: 1001-1012
[22] Tewari S, Jindal R, Kho YL, et al. Major pharmaceutical residues in wastewater treatment plants and receiving waters in Bangkok, Thailand, and associated ecological risks. Chemosphere, 2013, 91: 697-704
[23] der Beek TA, Weber FA, Bergmann A, et al. Pharmaceuticals in the environment: Global occurrences and perspectives. Environmental Toxicology and Chemistry, 2016, 35: 823-835
[24] Johnson AC, Jurgens MD, Nakada N, et al. Linking changes in antibiotic effluent concentrations to flow, removal and consumption in four different UK sewage treatment plants over four years. Environmental Pollution, 2017, 220: 919-926
[25] Dickinson JA, Chan CSY. Antibiotic use by practitioners in Hong Kong. Hong Kong Practitioner, 2002, 24: 282-291
[26] Abegglen C, Joss A, McArdell CS, et al. The fate of selected micropollutants in a single-house MBR. Water Research, 2009, 43: 2036-2046
[27] Gulkowska A, Leung HW, So MK, et al. Removal of antibiotics from wastewater by sewage treatment facilities in Hong Kong and Shenzhen, China. Water Research, 2008, 42: 395-403
[28] Klein EY, Van Boeckel T, Martinez E, et al. Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115: 3463-3470
[29] Zhang YZ, Wang B, Cagnetta G, et al. Typical pharmaceuticals in major WWTPs in Beijing, China: Occurrence, load pattern and calculation reliability. Water Research, 2018, 140: 291-300
[30] 胡伟. 天津城市水、土环境中典型药物与个人护理品(PPCPs)分布及其复合雌激素效应研究. 博士论文. 天津: 南开大学, 2011
[31] Xu WH, Zhang G, Zou SC, et al. Determination of selected antibiotics in the Victoria Harbour and the Pearl River, South China using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. Environmental Pollution, 2007, 145: 672-679
[32] Peng XZ, Tan JH, Tang CM, et al. Multiresidue determination of fluoroquinolone, sulfonamide, trimethoprim, and chloramphenicol antibiotics in urban waters in China. Environmental Toxicology and Chemistry, 2008, 27: 73-79
[33] 徐维海. 典型抗生素类药物在珠江三角洲水环境中的分布、行为与归宿. 博士论文. 广东: 中国科学院研究生院(广州地球化学研究所), 2007
[34] 张晓娇, 柏杨巍, 张远, 等. 辽河流域地表水中典型抗生素污染特征及生态风险评估. 环境科学, 2017, 38(11): 4553-4561
[35] Xu WH, Zhang G, Zou SC, et al. A preliminary investigation on the occurrence and distribution of antibiotics in the Yellow River and its tributaries, China. Water Environment Research, 2009, 81: 248-254
[36] Yan C, Yi Y, Zhou JL, et al. Antibiotics in the surface water of the Yangtze Estuary: Occurrence, distribution and risk assessment. Environmental Pollution, 2013, 175: 22-29
[37] Chang X, Meyer MT, Liu X, et al. Determination of antibiotics in sewage from hospitals, nursery and slaughter house, wastewater treatment plant and source water in Chongqing region of Three Gorge Reservoir in China. Environmental Pollution, 2010, 158: 1444-1450
[38] 杨尚乐, 王旭明, 王伟华, 等. 松花江哈尔滨段及阿什河抗生素的分布规律与生态风险评估. 环境科学, 2021, 42(1): 136-146
[39] 刘瀚阳. 典型抗生素在淮河流域(安徽段)水生生态系统中的分布特征、沉降趋势及其风险评估. 硕士论文. 合肥: 安徽师范大学, 2020
[40] Li N, Zhang XB, Wu W, et al. Occurrence, seasonal variation and risk assessment of antibiotics in the reservoirs in North China. Chemosphere, 2014, 111: 327-335
[41] Shimizu A, Takada H, Koike T, et al. Ubiquitous occurrence of sulfonamides in tropical Asian waters. Science of the Total Environment, 2013, 452: 108-115
[42] Liu XH, Lu SY, Guo W, et al. Antibiotics in the aquatic environments: A review of lakes, China. Science of the Total Environment, 2018, 627: 1195-1208
[43] Li W, Shi Y, Gao L, et al. Occurrence of antibiotics in water, sediments, aquatic plants, and animals from Baiyangdian Lake in North China. Chemosphere, 2012, 89: 1307-1315
[44] Cheng D, Liu X, Wang L, et al. Seasonal variation and sediment-water exchange of antibiotics in a shallower large lake in North China. Science of the Total Environment, 2014, 476: 266-275
[45] 雷晓宁. 新疆典型湖泊中抗生素的污染状况与分布特征. 硕士论文. 石河子: 石河子大学, 2014
[46] Xu J, Zhang Y, Zhou CB, et al. Distribution, sources and composition of antibiotics in sediment, overlying water and pore water from Taihu Lake, China. Science of the Total Environment, 2014, 497: 267-273
[47] Ding H, Wu Y, Zhang W, et al. Occurrence, distribution, and risk assessment of antibiotics in the surface water of Poyang Lake, the largest freshwater lake in China. Chemosphere, 2017, 184: 137-147
[48] Tang J, Zhang FH, Wang CC, et al. Investigation of sulfonamide antibiotics residue in the water of Chaohu Lake and its inlet rivers. Journal of Safety and Environment, 2014, 14: 334-338
[49] Wei Y, Zhang Y, Xu J, et al. Simultaneous quantification of several classes of antibiotics in water, sediments, and fish muscles by liquid chromatography-tandem mass spectrometry. Frontiers of Environmental Science & Engineering, 2014, 8: 357-371
[50] 丁腾达, 李雯, 阚啸林, 等. 水环境中药物和个人护理品(PPCPs)的污染现状及对藻类的毒性研究进展. 应用生态学报, 2019, 30(9): 3252-3264
[51] Moro I, Rocca NL, Rascio N. Photosynthetic apparatus in cyanobacteria and microalgae// Pessarakli M, ed. Handbook of Photosynthesis. Abingdon, UK: Taylor & Francis, 2016: 369-396
[52] Kasai K, Kanno T, Endo Y, et al. Guanosine tetra- and pentaphosphate synthase activity in chloroplasts of a higher plant: association with 70S ribosomes and inhibition by tetracycline. Nucleic Acids Research, 2004, 32: 5732-5741
[53] Qian HF, Li JJ, Pan XJ, et al. Effects of streptomycin on growth of algae Chlorella vulgaris and Microcystis aeruginosa. Environmental Toxicology, 2012, 27: 229-237
[54] Du Y, Wang J, Zhu F, et al. Comprehensive assessment of three typical antibiotics on cyanobacteria (Microcystis aeruginosa): The impact and recovery capability. Ecotoxicology and Environmental Safety, 2018, 160: 84-93
[55] Wang M, Zhang Y, Guo P. Effect of florfenicol and thiamphenicol exposure on the photosynthesis and antioxidant system of Microcystis flos-aquae. Aquatic Toxicology, 2017, 186: 67-76
[56] Zhong XQ, Zhu YL, Wang YJ, et al. Effects of three antibiotics on growth and antioxidant response of Chlorella pyrenoidosa and Anabaena cylindrica. Ecotoxicology and Environmental Safety, 2021, 211: 111954
[57] Yang WW, Tang ZP, Zhou FQ, et al. Toxicity studies of tetracycline on Microcystis aeruginosa and Selenastrum capricornutum. Environmental Toxicology & Pharmacology, 2013, 35: 320-324
[58] Gill SS, Tuteja N. Polyamines and abiotic stress tolerance in plants. Plant Signaling & Behavior, 2010, 5: 26-33
[59] Tripathi BN, Mehta SK, Amar A, et al. Oxidative stress in Scenedesmus sp.: During short- and long-term exposure to Cu ²⁺ and Zn ²⁺. Chemosphere, 2006, 62: 538-544
[60] Grene AR, Neval E, Heath LS. Role of superoxide dismutases (SODs) in controlling oxidative stress in plants. Journal of Experimental Botany, 2002, 53: 1331-1341
[61] Kovalakova P, Cizmas L, McDonald TJ, et al. Occurrence and toxicity of antibiotics in the aquatic environment: A review. Chemosphere, 2020, 251: 1-15
[62] Nie XP, Liu BY, Yu HJ, et al. Toxic effects of erythromycin, ciprofloxacin and sulfamethoxazole exposure to the antioxidant system in Pseudokirchneriella subcapitata. Environmental Pollution, 2013, 172: 23-32
[63] Xiong JQ, Govindwar S, Kurade MB, et al. Toxicity of sulfamethazine and sulfamethoxazole and their removal by a green microalga, Scenedesmus obliquus. Chemosphere, 2019, 218: 551-558
[64] Pan Y, Yan SW, Li RZ, et al. Lethal/sublethal responses of Daphnia magna to acute norfloxacin contamination and changes in phytoplankton-zooplankton interactions induced by this antibiotic. Scientific Reports, 2017, 7: 40385
[65] Lopes TOM, Passos LS, Vieira LV, et al. Metals, arsenic, pesticides, and microcystins in tilapia (Oreochromis niloticus) from aquaculture parks in Brazil. Environmental Science and Pollution Research, 2020, 27: 20187-20200
[66] Jiang Y, Liu Y, Zhang J. Antibiotics induced alterations in cell density, photosynthesis, microcystin synthesis and proteomic expression of Microcystis aeruginosa during CuSO₄ treatment. Aquatic Toxicology, 2020, 222: 105473
[67] Wan JJ, Guo PY, Peng XF, et al. Effect of erythromycin exposure on the growth, antioxidant system and photosynthesis of Microcystis flos-aquae. Journal of Hazar-dous Materials, 2015, 283: 778-786
[68] Liu WH, Ming Y, Huang ZW, et al. Impacts of florfenicol on marine diatom Skeletonema costatum through photosynthesis inhibition and oxidative damages. Plant Physiology and Biochemistry, 2012, 60: 165-170
[69] Chen JQ, Guo RX. Access the toxic effect of the antibiotic cefrad-ine and its UV light degradation products on two freshwater algae. Journal of Hazardous Materials, 2012, 209: 520-523
[70] Abraham GY, Mathias AC, Ramatu IS, et al. The antibiotic ciprofloxacin alters the growth, biochemical composition, and antioxidant response of toxin-producing and non-toxin-producing strains of Microcystis. Journal of Applied Phycology, 2021, 33: 2145-2155
[71] Porsbring T, Blanck H, Tjellström H, et al. Toxicity of the pharmaceutical clotrimazole to marine microalgal communities. Aquatic Toxicology, 2009, 91: 203-211
[72] Rico A, Zhao WK, Gillissen F, et al. Effects of temperature, genetic variation and species competition on the sensitivity of algae populations to the antibiotic enrofloxacin. Ecotoxicology and Environmental Safety, 2018, 148: 228-236
[73] Baselga-Cervera B, Cordoba-Diaz M, García-Balboa C, et al. Assessing the effect of high doses of ampicillin on five marine and freshwater phytoplankton species: A biodegradation perspective. Journal of Applied Phycology, 2019, 31: 2999-3010
[74] 杨宇峰, 黄祥飞. 浮游动物生态学研究进展. 湖泊科学, 2000, 12(1): 81-89
[75] Yan Z, Yang Q, Wang X, et al. Correlation between antibiotic-induced feeding depression and body size reduction in zooplankton (rotifer, Brachionus calyciflorus): Neural response and digestive enzyme inhibition. Chemosphere, 2019, 218: 376-383
[76] Ahmad P, Latef A, Hashem A, et al. Nitric oxide mitigates salt stress by regulating levels of osmolytes and antioxidant enzymes in chickpea. Frontiers in Plant Science, 2016, 7: 347
[77] Zhang YX, Guo PY, Wu YM, et al. Evaluation of the subtle effects and oxidative stress response of chloramphenicol, thiamphenicol, and florfenicol in Daphnia magna. Environmental Toxicology and Chemistry, 2019, 3: 575-584
[78] Yu XJ, Zhao W, Li YJ, et al. Neurotoxicity comparison of two types of local anaesthetics: Amide-bupivacaine versus ester-procaine. Scientific Reports, 2017, 24: 45316
[79] Pan Y, Liu CE, Li F, et al. Norfloxacin disrupts Daphnia magna-induced colony formation in Scenedesmus quadricauda and facilitates grazing. Ecological Engineering, 2017, 102: 255-261
[80] Bownik A, Laska B, Bochra J, et al. Procaine penicillin alters swimming behaviour and physiological parameters of Daphnia magna. Environmental Science and Pollution Research, 2019, 26: 18662-18673
[81] Lovern SB, Strickler JR, Klaper R. Behavioral and physiological changes in Daphnia magna when exposed to nanoparticle suspensions (Titanium Dioxide, Nano-C60, and C60HxC70Hx). Environmental Science and Technology, 2007, 41: 4465-4470
[82] Bownik A, Kowalczyk M, Bańczerowski J. Lambda-cyhalothrin affects swimming activity and physiological responses of Daphnia magna. Chemosphere, 2019, 216: 805-811
[83] Rhee JS, Kim BM, Jeong CB, et al. Effect of pharmaceuticals exposure on acetylcholinesterase (AchE) activity and on the expression of AchE gene in the monogonont rotifer, Brachionus koreanus. Comparative Biochemistry & Physiology Part C Toxicology & Pharmacology. 2013, 158: 216-224
[84] Wan LL, Long YY, Hui J, et al. Effect of norfloxacin on algae-cladoceran grazer-larval damselfly food chains: Algal morphology-mediated trophic cascades. Chemosphere, 2020, 256: 127166
[85] Visser AW, Kiørboe T. Plankton motility patterns and en counter rates. Oecologia, 2006, 148: 538-546
[86] Pan Y, Zhang YS, Sun SC. Habitat orientation alters the outcome of interspecific competition: A microcosm study with zooplankton grazers. Ecology and Evolution, 2018, 8: 1-16
[87] Zhang YS, Pan Y, Chen HX, et al. Microcosm experimental evidence that habitat orientation affects phytoplankton-zooplankton dynamics. Scientific Reports, 2017, 7: 1443
[88] 张丙行, 朱韩, 江姗, 等. 青霉素钠对萼花臂尾轮虫适合度的促进作用及其与藻密度的关系. 生态学报, 2021, 41(11): 4418-4427
[89] Taghavi D, Farhadian O, Soofiani NM, et al. Effects of different light/dark regimes and algal food on growth, fecundity, ephippial induction and molting of freshwater cladoceran, Ceriodaphnia quadrangular. Aquaculture, 2013, 410: 190-196
[90] Tkaczyk A, Bownik A, Dudka J, et al. Daphnia magna model in the toxicity assessment of pharmaceuticals: A review. Science of the Total Environment, 2020, 763: 143038
[91] 项贤领, 朱晔璘, 徐秋磊, 等. 盐酸四环素浓度和食物密度对萼花臂尾轮虫生活史特征的综合影响. 生态学报, 2017, 37(22): 7718-7728
[92] Ji K, Kim S, Han S, et al. Risk assessment of chlortetracycline, oxytetracycline, sulfamethazine, sulfathiazole, and erythromycin in aquatic environment: Are the current environmental concentrations safe? Ecotoxicology, 2012, 21: 2031-2050
[93] Perera E, Rodriguez-Viera L, Rodriguez-Casariego J, et al. Dietary protein quality differentially regulates trypsin enzymes at the secretion and transcription level in Panulirus argus by distinct signaling pathways. Journal of Experimental Biology, 2012, 215: 853-862
[94] Li Y, Ma YF, Yang LK, et al. Effects of azithromycin on feeding behavior and nutrition accumulation of Daphnia magna under the different exposure pathways. Ecotoxicology and Environmental Safety, 2020, 197: 110573
[95] Toumi H, Boumaiza M, Millet M, et al. Effects of deltamethrin (pyrethroid insecticide) on growth, reproduction, embryonic development and sex differentiation in two strains of Daphnia magna (Crustacea, Cladocera). Science of the Total Environment, 2013, 458: 47-53
[96] Blaser M, Bork P, Fraser C, et al. The microbiome explored: Recent insights and future challenges. Nature Reviews Microbiology, 2013, 11: 213-217
[97] Gorokhova E, Rivetti C, Furuhagen S, et al. Bacteria-Mediated effects of antibiotics on Daphnia nutrition. Environmental Science & Technology, 2015, 49: 5779-5787
[98] Akbar S, Gu L, Sun YF, et al. Changes in the life history traits of Daphnia magna are associated with the gut microbiota composition shaped by diet and antibiotics. Science of the Total Environment, 2020, 705: 135827
[99] Christensen AM, Ingerslev F, Baun A. Ecotoxicity of mixtures of antibiotics used in aquacultures. Environmental Toxicology and Chemistry, 2006, 25: 2208-2215
[100] Wollenberger L, Halling-Sørensen B, Kusk KO. Acute and chronic toxicity of veterinary antibiotics to Daphnia magna. Chemosphere, 2000, 40: 723-730
[101] Martins A, Guimarães L, Guilhermino L. Chronic toxicity of the veterinary antibiotic florfenicol to Daphnia magna assessed at two temperatures. Environmental Toxicology and Pharmacology, 2013, 36: 1022-1032
[102] Peeters F, Li J, Straile D, et al. Influence of low and decreasing food levels on Daphnia-algal interactions: Numerical experiments with a new dynamic energy budget model. Ecological Modelling, 2010, 221: 2642-2655
[103] Xue X, Wang LH, Xing HR, et al. Characteristics of phytoplankton-zooplankton communities and the roles in the transmission of antibiotic resistance genes under the pressure of river contamination. Science of the Total Environment, 2021, 780: 146452
[104] Chia MA, Lorenzi AS, Ameh I, et al. Susceptibility of phytoplankton to the increasing presence of active pharmaceutical ingredients (APIs) in the aquatic environment: A review. Aquatic Toxicology, 2021, 234: 146452
[105] Greenberg BM, Huang XD, Dixon DG. Applications of the aquatic higher plan Lemna gibba for ecotoxicological risk assessment. Journal of Aquatic Ecosystem Health, 1992, 1: 147-155
[106] Klassen A, Faccio AT, Canuto GAB, et al. Metabolomics: Definitions and significance in systems biology. Advances in Experimental Medicine and Biology, 2017, 965: 3-17
[107] Pan Y, Long YY, Hui J, et al. Microplastics can affect the trophic cascade strength and stability of plankton ecosystems via behavior-mediated indirect interactions. Journal of Hazardous Materials, 2022, 430: 128415
[108] Gothwal R, Thatikonda S. Mathematical model for the transport of fluoroquinolone and its resistant bacteria in aquatic environment. Environmental Science and Pollution Research, 2017, 25: 20439-20452