Abstract: The impacts of global climate change and human disturbance on terrestrial ecosystems has been expanding in intensity and scope. However, there is a lack of evaluation methods for large-scale heterogeneous landscape systems during ecosystem integrity assessment. From the perspective of landscape ecology, this study chose the indicators of landscape structure and landscape stability to comprehensively evaluate regional landscape change characteristics and ecosystem integrity dynamics of Greater Hinggan Mountains area using land use data and NPP data of 2005, 2010 and 2015 with GIS data processing and analysis platform. The results showed that Greater Hinggan Mountains area was dominated by forest land. The dominance degree of forest land was stable at 64.9%, which was much higher than the grassland that with the second dominance. The landscape diversity index was 0.59 in all three periods, accounting for 42.4% of the maximum value of landscape diversity index. Such a result indicated that the landscape resistance was stable in this area. From the view of landscape biomass, farmland and residential land had increased year by year, while forest area had decreased year by year, indicating that the effects of human disturbance on Greater Hinggan Mountains area were increasing.