环境中抗生素抗性基因的水平传播扩散

应用生态学报

环境中抗生素抗性基因的水平传播扩散

杨凤霞¹,毛大庆^2**,罗义³,汪庆⁴,母全华⁴

(¹沈阳药科大学生命科学与生物制药学院, 沈阳 110016; ²天津大学环境科学与工程学院, 天津 300072; ³南开大学环境科学与工程学院教育部环境污染过程与基准重点实验室, 天津 300071; ⁴南开大学环境科学与工程学院, 天津 300071 )

出版日期:2013-10-18 发布日期:2013-10-18

Horizontal transfer of antibiotic resistance genes in the environment.

YANG Feng-xia¹, MAO Da-qing², LUO Yi³, WANG Qing⁴, MU Quan-hua^4

(¹College of Life Science and Biopharmaceutical, Shenyang Pharmaceutical University, Shenyang 110016, China; ²College of Environmental Science and Engineering, Tianjin University, Tianjin 300072, China; ^3Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China; ^{ 4}College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China)

Online:2013-10-18 Published:2013-10-18

摘要/Abstract

摘要： 抗生素抗性基因作为一类新型环境污染物，其在不同环境介质中的传播扩散可能比抗生素本身的环境危害更大，其中，水平基因转移是抗生素抗性基因传播的重要方式，是造成抗性基因环境污染日益严重的原因之一.本文系统阐述了抗生素抗性基因在环境中发生水平转移的主要分子传播元件及其影响因素，这对于正确揭示抗性基因的分子传播机制具有重要意义.结合多重抗药性的传播扩散机制，探讨了行之有效的遏制抗生素抗性基因传播扩散的方法和途径，并针对目前的污染现状，对今后有关抗生素抗性基因水平转移的研究重点进行了展望.

Abstract: The transfer of antibiotic resistance genes (ARGs), a new type of environmental pollutants, could have more adverse effects on the environment than the ARGs themselves, while the horizontal gene transfer (HGT) could be the most important propagation pathways of the ARGs, being one of the reasons for the growing pollution of ARGs in the environment. This paper systematically elaborated the molecular elements of the horizontal transfer of ARGs and the related affecting factors, which was of significance for investigating the molecular mechanisms of the horizontal transfer of the ARGs. In combining with the phylogenetic mechanisms of multiple antibiotic resistances, this paper also provided effective strategies to reduce the transfer and proliferation of ARGs in the environment. Based on the present contamination situations, the further researches on the horizontal transfer of ARGs in the environment were prospected.

杨凤霞1,毛大庆2**,罗义3,汪庆4,母全华4. 环境中抗生素抗性基因的水平传播扩散[J]. 应用生态学报.

YANG Feng-xia1, MAO Da-qing2, LUO Yi3, WANG Qing4, MU Quan-hua4. Horizontal transfer of antibiotic resistance genes in the environment.[J]. Chinese Journal of Applied Ecology.