Abstract: Effects of diets on growth, serum biochemical indices, and enzyme activities related to lipid metabolism in fingerlings Coilia nasus at age of 6 months were investigated during 60-day experiment in this study. Fingerlings with similar body length and mass were fed with one of 3 types of diets (diet 1: soft pellet; diet 2: soft pellet mixed with fish oil; diet 3: slowsinking hard pellet). Fish fed with diets 2 or 3 had significantly higher total body mass, rate of mass gain, specific growth rate, and fullness coefficient than those fed with diet 1. Fish fed with diet 3 exhibited the lower food coefficient compared to those fed with diets 1 or 2. Growth traits (length, length to mass ratio, length to width ratio, hepatopancreas somatic indices and viscera somatic index) and serum biochemical indices (total protein, albumin, blood glucose, cholesterol 〖JP2〗and triglycerides) in all three treatments were not significantly different. Fish fed with diet 1 exhibited significantly higher carnitine palmitoyltransferase-I than those fed with diets 2 or 3, while fish fed with diet 2 exhibited significantly lower carnitine palmitoyltransferase-II. However, amylase, pepsin, lipase activity, lipoprotein lipase and acetyl-coa carboxylase had no significant difference in fish body among all groups. Results suggested that fish oil as a diet supplement highly facilitated fish growing. The slow-sinking pellet had the highest utilization efficiency and was suitable to feed fish fingerlings of C.nasus.