Abstract: To establish an optimum combination of water and nitrogen for spring under permanent raised bed (PRB) tillage, a field investigation was carried out to assess effects of irrigation and N application on root growth, yield, irrigation water productivity and N efficiency. The experiment followed a completely randomized split-plot design, taking furrow irrigation 1200 m³·hm^-2(W₁), 2400 m³·hm^-2(W₂), 3600 m³·hm^-2(W₃) as main plot treatments, and N rates (0, 90, 180, 270 kg·hm^-2) the sub-plot treatments. Our results showed that the root mass density (RWD) was significantly affected by irrigation and N application, the RWD of spring wheat reached a maximum at the filling stage, followed by a slow decline until maturity, while the effect of N on RWD depended on soil water conditions. The application of N₂ produced the maximum RWD under W₂ irrigation, the application of N₁ produced the maximum RWD under W₁ irrigation, and the application of N₃ produced the maximum RWD under W₃ irrigation. The order of irrigation regime effect on RWD of spring wheat was W₂>W₃>W₁. The order of irrigation regime and N rate effect on RWD of spring wheat was irrigation>N>irrigation and N interaction. W₂N₂ treatment produced the highest RWD value. The root-to-shoot ratio (R/S) descended with the rising of irrigation water and nitrogen amount, and the combined treatment (W₁N₀) produced the maximum R/S. The root system was mainly distributed in the 0-40 cm soil layer, in which the RWD accounted for 85% of the total RWD in 0-80 cm soil depth. There was a significantly positive relationship between RWD in the 0-40 cm and the yield of spring wheat, RWD in the 40-60 cm had higher linear dependence on the yield of spring wheat. W₂ increased the proportion of RWD in the deep soil layer (40-60 cm). The irrigation and N rate had a significant impact on biomass and grain yield of spring wheat, the biomass increased as the N rate and water amount increased, W₂N₂ treatment produced the highest grain yield, irrigation water productivity descended with increasing the irrigation amount, and the nitrogen agronomic efficiency descended with increasing N rate. It was concluded that the irrigation level W₂(2400 m³·hm^-2) and nitrogen level N₂(180 kg·hm^-2) could be recommended as the best combination of water and N, which promoted the root growth, improved grain yield, water and nitrogen use efficiencies of spring wheat production under PRB tillage in the experimental area.