Abstract: Earthworm lives in the environment flocked with pathogens,but few are infected due to the earthworm’s unique antibiotic and immune system.In this paper,the research advance in this domain was reviewed from the aspects of antibiotic barrier,cell immunity,and humoral immunity.Antibiotic barrier mainly includes body wall,alimentary canal and parietal mucus,cell immunity represents phagocytosis and encapsulation responses,while humoral immunity gives priority to unspecific immune system.The main antibacterial materials in the coelomic fluid of earthworm are antigen-binding proteins,agglutinins,antibacterial proteins,and lysozyme.

Key words: Southern margin of Taklamakan Desert, Oases ecosystem, Sustainable management, Optimal model