In order to predict effects of climate changing on growth, quality and grain yields of spring wheat, a field experiment was conducted to investigate the effects of air temperature increases (0 ℃, 1.0 ℃, 2.0 ℃ and 3.0 ℃) and precipitation variations (decrease 20%, unchanging and increase 20%) on grain yields, quality, diseases and insect pests of spring wheat at the Dingxi Arid Meteorology and Ecological Environment Experimental Station of the Institute of Arid Meteorology of China Meteorological Administration(35°35′ N,104°37′ E). The results showed that effects of precipitation variations on kernel numbers of spring wheat were not significant when temperature increased by less than 2.0 ℃, but was significant when temperature increased by 3.0 ℃. Temperature increase enhanced kernel numbers, while temperature decrease reduced kernel numbers. The negative effect of temperature on thousandkernel mass of spring wheat increased with increasing air temperature. The sterile spikelet of spring wheat response to air temperature was quadratic under all precipitation regimes. Compared with control (no temperature increase), the decreases of grain yield of spring wheat when air temperature increased by 1.0 ℃, 2.0 ℃ and 3.0 ℃ under each of the three precipitation conditions (decrease 20%, no changing and increase 20%) were 12.1%, 24.7% and 42.7%, 8.4%, 15.1% and 21.8%, and 9.0%, 15.5% and 22.2%, respectively. The starch content of spring wheat decreased and the protein content increased with increasing air temperature. The number of aphids increased when air temperature increased by 2.0 ℃, but decreased when air temperature increased by 3.0 ℃. The infection rates of rust disease increased with increasing air temperature.