Abstract: The alpine desert of QinghaiTibet Plateau (QTP) provides the largest habitats for those endangered ungulates (e.g.， Tibetan antelope, Tibetan Kiang and wild yak) on the earth. However, human disturbance especially infrastructure constructions (e.g.， railway & highway) has increasingly fragmented the habitats of those endangered ungulates by disturbing and interrupting their ecological corridors for their seasonal migration. Aiming at identifying the potential ecological corridors for Tibetan antelope, a GISbased modelLinkage Mapper was used to model and detect the potential ecological corridors of Tibetan antelope based on the principle of least cost path. Three categories of ecological corridors， i.e., closed (inside reserves), linking (linking the reserves) and open (starting from reserve but ending outside) corridors were distinguished by their spatial interactions with existing major national nature reserves (i.e., Altun, Kekexili and Qiangtang NNRs) in the alpine desert of QTP, and their spatial patterns, conservation status associated with human disturbance were also examined. Although our research indicated a general ecological integration of both habitats and ecological corridors in the alpine desert ecosystem, increasing human disturbance should not be ignored, which particularly partially undermined the functioning of those ecological corridors linking the nature reserves. Considering disadvantages of prevailing separate administrative structure of nature reserve on the effective conservation of ecological corridors for those endangered ungulates, a coordinative conservation network among these major national nature reserves should be established to ensure the unified transboundary conservation efforts and to enhance its overall conservation efficacy by sharing information, knowledge and optimizing conservation resources.