Abstract: Vitis heyneana and V. davidii are two wild wine grape varieties that originate from China. In this study, we used the principle of maximum entropy in terms of sufficiency and necessity to identify the dominant climatic factors (among the many climatic factors that were brought up by previous relevant studies) affecting the planting distribution of both varieties in China. Based on the probability of planting distribution determined by the comprehensive effect of these dominant climatic factors, we further analyzed the climatic suitability in China for both wild varieties. The results showed that the four dominant climatic factors affecting the spatial distribution of both varieties were annual sunshine duration, precipitation during the flowering stage in May, annual extreme minimum temperature, and average temperature during the coldest month of January. The optimal wine grape-growing subregions for both varieties were mainly located in the western and southern parts of Hunan, the north-central part of Guangxi, the southeastern part of Guizhou, and the central part of Chongqing. The areas of optimal, suitable, and sub-suitable subregions for planting V. heyneana and V. davidii accounted for 2%, 14%, and 16% of the total area of the research region, respectively. In the optimal/suitable subregions for planting both varieties, annual sunshine duration was between 1200-1800 h, annual extreme minimum temperature was above -8 ℃, average temperature during the coldest month of January was between 2-13 ℃, and monthly precipitation in May was between 110-320 mm.