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Effects of nonylphenol on proliferation and anti-oxidative functions of Carassius auratus primary culture hepatecytes.

ZHANG Yi;ZHANG Gao-feng;WEI Hua   

  1. College of Fisheries and Life Science, Shanghai Ocean University, Shanghai 201306, China
  • Received:2008-07-15 Revised:1900-01-01 Online:2009-02-20 Published:2009-02-20

Abstract: The study on the proliferation and anti-oxidative functions of Cara ssius auratus primary culture hepatecytes under effects of different concentra tion nonylphenol showed that at all test concentrations of nonylphenol, the prol iferation of the hepatecytes was inhibited. High concentration (10-3 mol· L-1) nonylphenol had significant inhibitory effect, and induced an apparen t morphological alteration of the hepatecytes. Nonylphenol upset the balance of hepatecytes anti-oxidative system through decreasing the activities of superoxi de dismutase (SOD) and catalase (CAT) while increasing the hydroxyl free radical concentration. Nonylphenol also caused the oxidative damage on the hepatecytes, resulting in the increase of malondialdehyde (MDA) concentration in cell cultur e medium. The nonylphenol-induced oxidative stress engendered a series of in vi tro toxic effects on the primary culture hepatecytes of C. auratus.

Key words: Three Gorges Reservoir Area, Pinus massoniana plantation, root, litterfall, soil physical and chemical properties.