Abstract: By using artificial soil test, the effects of different concentration
albendozole on Eisenia foetida’s growth, survival, reproduction, and activities
 of superoxide dismutase (SOD), glutathione-sulfurtransferase (GST-S) and acet
ylcholine esterase (AchE) were studied. Low concentration (5 mg·kg-1)  albe
ndazole inhibited the reproduction of E. foetida significantly (P<005), an
d 7 mg·kg-1 of albendazole had significant effects on the growth and surv
ival of E. foetida. When the albendazole concentration reached to 10 mg·kg
-1, the mortality of E. foetida was as high as 53%. There was a signif
icant dose-response relationship between the exposure concentration of albendaz
ole and the inhibition rate of E. foetida’s growth and reproduction. After
21 days’ albendazole exposure, the SOD and GST-S activities were affected sign
ificantly, but no significant dose-response relationship was observed. Albendaz
ole exposure had less effects on AchE activity. In sum, albendazole had direct
 toxicity on soil animals, with a potential ecological risk.

Key words: Eisenia foetida, albendazole, ecotoxicity, antioxidant enzyme system, mine wastewater, irrigation, physiological character, winter wheat, heavy metal.